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| カタログ番号 | HT365014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-UBD Polyclonal Antibody (HT365014) is a rabbit polyclonal antibody detecting UBD in ELISA, IHC, WB. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human UBD (Met1-Gly165). | ||||||||
| ターゲット | Diubiquitin, UBD, Ubiquitin-like protein FAT10, Ubiquitin D, FAT10 | ||||||||
| エンドトキシンレベル | Please contact with the lab for this information. | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | O15205 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | Ubiquitin D (UBD) is a ~18 kDa protein. Ubiquitin-like protein modifier which can be covalently attached to target proteins and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Conjugation to the target protein is activated by UBA6 via adenylation of its C-terminal glycine. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). 1. Hipp, MS. et al. (2005) Molecular and cellular biology 25, 3483-91. PMID: 15831455 2. Schmidtke, G. et al. (2006) The Journal of biological chemistry 281, 20045-54. PMID: 16707496 3. Schmidtke, G. et al. (2009) FEBS letters 583, 591-4. PMID: 19166848 4. Chiu, YH. et al. (2007) Molecular cell 27, 1014-23. PMID: 17889673 5. Truongvan, N. et al. (2022) Nature communications 13, 4789. PMID: 35970836 6. Gong, P. et al. (2010) Journal of the American Society of Nephrology : JASN 21, 316-26. PMID: 19959714 7. Ebstein, F. et al. (2009) The international journal of biochemistry & cell biology 41, 1205-15. PMID: 19028597 8. Ren, J. et al. (2006) The Journal of biological chemistry 281, 11413-21. PMID: 16495226 9. Kalveram, B. et al. (2008) Journal of cell science 121, 4079-88. PMID: 19033385 10. Ross, MJ. et al. (2006) Journal of the American Society of Nephrology : JASN 17, 996-1004. PMID: 16495380 | ||||||||
| 注意事項 | For research use only. |
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