Anti-UCHL1 Polyclonal Antibody (HY589014)

Name: Anti-UCHL1 Polyclonal Antibody
Brand: abinScience
SKU: HY589014
Price: 168 USD
Availability: InStock

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50ug
100ug

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Aperçu

Numéro de catalogue

HY589014

Description

Anti-UCHL1 Polyclonal Antibody (HY589014) is a rabbit polyclonal antibody detecting UCHL1 in ELISA, IHC, WB. Suitable for Human, Mouse, Rat, Bovine, and Equus caballus.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

Reactivité des espèces

Human, Mouse, Rat

Applications

ELISA, IHC, WB

Espèce hôte

Rabbit

Clonalité

Polyclonal

Isotype

IgG

Immunogène

E. coli - derived recombinant Human UCHL1 (Gln2-Ala223).

Cible

UCH-L1, PGP 9.5, UCHL1, Ubiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin thioesterase L1, Neuron cytoplasmic protein 9.5, PGP9.5

Purification

Purified by antigen affinity column.

Numéro d'accès

P09936

Forme

Liquid

Tampon de stockage

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) is a ~24 kDa protein. Deubiquitinase that plays a role in the regulation of several processes such as maintenance of synaptic function, cardiac function, inflammatory response or osteoclastogenesis. Abrogates the ubiquitination of multiple proteins including WWTR1/TAZ, EGFR, HIF1A and beta-site amyloid precursor protein cleaving enzyme 1/BACE1. In addition, recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin to maintain a stable pool of monoubiquitin that is a key requirement for the ubiquitin-proteasome and the autophagy-lysosome pathways. Regulates amyloid precursor protein/APP processing by promoting BACE1 degradation resulting in decreased amyloid beta production. Plays a role in the immune response by regulating the ability of MHC I molecules to reach cross-presentation compartments competent for generating Ag-MHC I complexes.

1. Zhang, M. et al. (2012) Journal of neurochemistry 120, 1129-38. PMID: 22212137

2. Bilguvar, K. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 3489-94. PMID: 23359680

3. Goto, Y. et al. (2015) Nature communications 6, 6153. PMID: 25615526

4. Liu, Y. et al. (2002) Cell 111, 209-18. PMID: 12408865

5. Larsen, CN. et al. (1996) Biochemistry 35, 6735-44. PMID: 8639624

6. Leroy, E. et al. (1998) Nature 395, 451-2. PMID: 9774100

Note

For research use only.

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Fiche technique

Anti-UCHL1 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Protéines Recombinantes

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Kits d'Essai

Anti-UCHL1 Polyclonal Antibody (HY589014)

Aperçu

Images

Reférences

Fiche technique

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