Anti-VAPA Polyclonal Antibody (HV508014)

Name: Anti-VAPA Polyclonal Antibody
Brand: abinScience
SKU: HV508014
Price: 168 USD
Availability: InStock

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HV508014

説明

Anti-VAPA Polyclonal Antibody (HV508014) is a rabbit polyclonal antibody detecting VAPA in ELISA, IHC, WB. Suitable for Human, Mouse, Rat.

Highlights

●Affinity Purified — Minimal background and high purity for reliable results.
●Multi-Application — Validated across multiple applications.
●Multi-Species — Cross-reactive for translational research.

種反応性

Human, Mouse, Rat

アプリケーション

ELISA, IHC, WB

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

免疫原

E. coli - derived recombinant Human VAPA (Met8-Met132).

ターゲット

33 kDa VAMP-associated protein, VAP-33, VAP33, VAPA, VAMP-associated protein A, VAMP-A, VAP-A, Vesicle-associated membrane protein-associated protein A

精製

Purified by antigen affinity column.

アクセッション番号

Q9P0L0

形態

Liquid

保存バッファー

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Vesicle-associated membrane protein-associated protein A (VAPA) is a ~27 kDa protein. Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes. Via interaction with WDR44 participates in neosynthesized protein export. In addition, recruited to the plasma membrane through OSBPL3 binding. The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface.

1. Lucken-Ardjomande Häsler, S. et al. (2020) The Journal of cell biology 219. PMID: 32344433

2. Di Mattia, T. et al. (2020) The EMBO journal 39, e104369. PMID: 33124732

3. Weber-Boyvat, M. et al. (2015) Experimental cell research 331, 278-91. PMID: 25447204

4. Lehto, M. et al. (2005) Experimental cell research 310, 445-62. PMID: 16143324

5. Weir, ML. et al. (2001) Biochemical and biophysical research communications 286, 616-21. PMID: 11511104

6. Saita, S. et al. (2009) The Journal of biological chemistry 284, 13766-13777. PMID: 19289470

注意事項

For research use only.

イメージ

参考文献

データシート

Anti-VAPA Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

組換えタンパク質

抗体

アッセイキット

Anti-VAPA Polyclonal Antibody (HV508014)

概要

イメージ

参考文献

データシート

SDS