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| カタログ番号 | HV017014 | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 説明 |
Anti-WWTR1 Polyclonal Antibody (HV017014) is a rabbit polyclonal antibody detecting WWTR1 in ELISA, IHC, WB. Suitable for Human, Mouse, and Dog.
Highlights
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| 種反応性 | Human, Mouse | ||||||||
| アプリケーション | ELISA, IHC, WB | ||||||||
| 宿主種 | Rabbit | ||||||||
| クローン性 | Polyclonal | ||||||||
| アイソタイプ | IgG | ||||||||
| 免疫原 | E. coli - derived recombinant Human WWTR1 (Met1-Leu400). | ||||||||
| ターゲット | Transcriptional coactivator with PDZ-binding motif, TAZ, WW domain-containing transcription regulator protein 1, WWTR1 | ||||||||
| 精製 | Purified by antigen affinity column. | ||||||||
| アクセッション番号 | Q9GZV5 | ||||||||
| 形態 | Liquid | ||||||||
| 保存バッファー | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||||||
| 背景 | WW domain-containing transcription regulator protein 1 (WWTR1) is a ~44 kDa protein. Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. In conjunction with YAP1, involved in the regulation of TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation. Plays a key role in coupling SMADs to the transcriptional machinery such as the mediator complex. 1. Kanai, F. et al. (2000) The EMBO journal 19, 6778-91. PMID: 11118213 2. Lei, QY. et al. (2008) Molecular and cellular biology 28, 2426-36. PMID: 18227151 3. Lucci, V. et al. (2013) Gene 529, 300-6. PMID: 23911299 4. Di Palma, T. et al. (2009) Experimental cell research 315, 162-75. PMID: 19010321 5. Varelas, X. et al. (2008) Nature cell biology 10, 837-48. PMID: 18568018 | ||||||||
| 注意事項 | For research use only. |
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