Astegolimab ELISA Kit (DX139018)

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Каталожный номер	DX139018
Описание	Astegolimab ELISA Kit (DX139018) — Quantitative sandwich ELISA for Astegolimab. Sample: Plasma, Serum. Range: 0.31-5 μg/mL. Sensitivity: 0.156 μg/ml. Highlights ●Sandwich Format — High specificity, reliable quantification. ●High Sensitivity — Optimized for low-abundance target detection. ●Ready-to-Use — Complete kit with pre-coated plates included.
Тип образца	Plasma, Serum
Чувствительность	0.156 μg/ml
Диапазон	0.31-5 μg/mL
Номер доступа	Q01638
Применения	ELISA
Метод обнаружения	Colorimetric
Тип анализа	Quantitative
Восстановление	80-120%
Доставка	2-8 ℃
Устойчивость и хранение	The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.
Характеристики	Astegolimab
Альтернативные названия	AMG-282, MSTT-1041A, RG-6149, RO-7187807, 2173054-79-8
Фон	Interleukin-1 receptor-like 1 (Astegolimab) is a ~63 kDa protein. Receptor for interleukin-33 (IL-33) which plays crucial roles in innate and adaptive immunity, contributing to tissue homeostasis and responses to environmental stresses together with coreceptor IL1RAP. Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable). Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. 1. Yi, XM. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2116279119. PMID: 35238669 2. Schmitz, J. et al. (2005) Immunity 23, 479-90. PMID: 16286016
Примечание	For Research Use Only.