Disitamab ELISA Kit (DY286018)

データシート製品共有情報コピー

概要
イメージ
参考文献
データシート
SDS

カタログ番号	DY286018
サンプルタイプ	Plasma, Serum
感度	0.156 μg/ml
レンジ	0.31-5 μg/mL
アクセッション番号	P04626
アプリケーション	ELISA
検出方法	Colorimetric
アッセイタイプ	Quantitative
回収率	80-120%
発送	2-8 ℃
安定性と保存	The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.
仕様	Disitamab
別名	RC48-0, Disitamab Vedotin, 2185868-98-6
背景	Receptor tyrosine-protein kinase erbB-2 (Disitamab) is a ~137 kDa protein. Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane.
参考文献	1. Deeks ED. Disitamab Vedotin: First Approval. Drugs. 2021;81(16):1929-1935. [DY286018] 2. Jiang J, et al. Preclinical safety profile of disitamab vedotin: a novel anti-HER2 antibody conjugated with MMAE. Toxicol Lett. 2020;324:30-37. [DY286018] 3. Huang L, Wang R, Xie K, et al. A HER2 target antibody drug conjugate combined with anti-PD-(L)1 treatment eliminates hHER2+ tumors in hPD-1 transgenic mouse model and contributes immune memory formation. Breast Cancer Res Treat. 2022;191(1):51-61. [DY286018]
注意事項	For Research Use Only.