Eldelumab ELISA Kit (DY524018)

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Каталожный номер	DY524018
Описание	Eldelumab ELISA Kit (DY524018) — Quantitative sandwich ELISA for Eldelumab. Sample: Plasma, Serum. Range: 0.31-5 μg/mL. Sensitivity: 0.156 μg/ml. Highlights ●Sandwich Format — High specificity, reliable quantification. ●High Sensitivity — Optimized for low-abundance target detection. ●Ready-to-Use — Complete kit with pre-coated plates included.
Тип образца	Plasma, Serum
Чувствительность	0.156 μg/ml
Диапазон	0.31-5 μg/mL
Номер доступа	P02778
Применения	ELISA
Метод обнаружения	Colorimetric
Тип анализа	Quantitative
Восстановление	80-120%
Доставка	2-8 ℃
Устойчивость и хранение	The stability of ELISA kit is determined by the loss rate of activity. The loss rate of this kit is less than 10% prior to the expiration date under appropriate storage condition.
Характеристики	Eldelumab
Альтернативные названия	BMS-936557, MDX-1100, 946414-98-8
Фон	C-X-C motif chemokine 10 (Eldelumab) is a ~10 kDa protein. Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. 1. Romagnani, P. et al. (2001) Blood 97, 601-7. PMID: 11157474 2. Sidahmed, AM. et al. (2012) Cytokine 59, 433-41. PMID: 22652417 3. Angiolillo, AL. et al. (1995) The Journal of experimental medicine 182, 155-62. PMID: 7540647 4. Smit, MJ. et al. (2003) Blood 102, 1959-65. PMID: 12750173 5. Gao, JM. et al. (2009) Acta pharmacologica Sinica 30, 193-201. PMID: 19151743 6. Cheeran, MC. et al. (2003) Journal of virology 77, 4502-15. PMID: 12663757
Примечание	For Research Use Only.