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InVivoMAb Anti-Human Thrombopoietin R/Tpo R Antibody (3D9) (HW601010)

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InVivoMAb Anti-Human Thrombopoietin R/Tpo R Antibody (3D9)
InVivoMAb Anti-Human Thrombopoietin R/Tpo R Antibody (3D9)
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Especificación:
  • 100ug
  • 1mg
Número:
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Vista general
Número de catálogoHW601010
Descripción
InVivoMAb Anti-Human CD110/TPOR Antibody (3D9) [3D9] (HW601010) is a human monoclonal antibody detecting TPO-R in Agonist, ELISA. Suitable for Human.
Reactividad de especiesHuman
AplicacionesAgonist, ELISA
Especie huéspedHuman
ClonalidadMonoclonal
IsotipoIgG1
ID de clon3D9
Objetivo TPO-R, TPOR, Thrombopoietin receptor, MPL, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, CD110
Nivel de endotoxinas Please contact with the lab for this information.
Pureza >95% as determined by SDS-PAGE.
Productos asociados pH 7.4 Dilution Buffer
Purificación Protein A/G purified from cell culture supernatant.
Número de acceso P40238
Forma Liquid
Buffer de almacenamiento 0.01M PBS pH 7.4

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Información de uso del producto
Aplicación Dilución
ELISA 1:2000-1:20000
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo

Thrombopoietin receptor (CD110/TPOR) is a ~71 kDa protein. Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K. In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production.

1. Royer, Y. et al. (2005) The Journal of biological chemistry 280, 27251-61. PMID: 15899890
2. Tsutsumi, N. et al. (2023) Cell 186, 4189-4203.e22. PMID: 37633268
Nota For research use only. Not suitable for clinical or therapeutic use.
Imágenes
  • InVivoMAb Anti-Human Thrombopoietin R/Tpo R Antibody (3D9)

    SDS-PAGE

    SDS-PAGE for InVivoMAb Anti-Human CD110/TPOR Antibody (3D9)

Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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