Anti-Human Thrombopoietin R/Tpo R Recombinant Antibody (VB22B) (HW601107)

Name: Anti-Human Thrombopoietin R/Tpo R Recombinant Antibody (VB22B)
Brand: abinScience
SKU: HW601107
Price: 191 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.	HW601107
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG1, kappa
Clone ID	VB22B
Clonality	Monoclonal
Target	TPO-R, TPOR, Thrombopoietin receptor, MPL, Myeloproliferative leukemia protein, Proto-oncogene c-Mpl, CD110
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P40238
Form	Liquid
Storage buffer	0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Background	Thrombopoietin receptor (CD110/MPL) is a ~71 kDa protein. Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K. In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production. 1. Royer, Y. et al. (2005) The Journal of biological chemistry 280, 27251-61. PMID: 15899890 2. Tsutsumi, N. et al. (2023) Cell 186, 4189-4203.e22. PMID: 37633268
Note	For research use only.

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Bioactivity

Detects CD110/MPL in indirect ELISAs.
Western blot

Western blot analysis was performed using anti-CD110/MPL monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD110/MPL (Catalog No: HW601011)
Lane 2: negative control