InVivoMAb Anti-Human Fc gamma RIIIA/CD16a Antibody (LNK16) (HY386040)

Name: InVivoMAb Anti-Human Fc gamma RIIIA/CD16a Antibody (LNK16)
Brand: abinScience
SKU: HY386040
Price: 370 USD
Availability: InStock

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100ug
1mg

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Número de catálogo	HY386040
Descripción	InVivoMAb Anti-Human CD16a/FCGR3A Antibody (LNK16) [LNK16] (HY386040) is a mouse monoclonal antibody detecting Low affinity immunoglobulin gamma Fc region receptor III-A in Blocking, ELISA. Suitable for Human.
Reactividad de especies	Human
Aplicaciones	Blocking, ELISA
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG2a, kappa
ID de clon	LNK16
Objetivo	Low affinity immunoglobulin gamma Fc region receptor III-A, IgG Fc receptor III-A, CD16-II, CD16a antigen, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcgammaRIIIA, FcR-10, IgG Fc receptor III-2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, IGFR3
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>95% as determined by SDS-PAGE.
Productos asociados	pH 7.4 Dilution Buffer
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P08637
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo	Low affinity immunoglobulin gamma Fc region receptor III-A (CD16a/FCGR3A) is a ~29 kDa protein. Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Optimally activated upon binding of clustered antigen-IgG complexes displayed on cell surfaces, triggers lysis of antibody-coated cells, a process known as antibody-dependent cellular cytotoxicity (ADCC). Does not bind free monomeric IgG, thus avoiding inappropriate effector cell activation in the absence of antigenic trigger. Mediates IgG effector functions on natural killer (NK) cells. Binds antigen-IgG complexes generated upon infection and triggers NK cell-dependent cytokine production and degranulation to limit viral load and propagation. 1. Hezareh, M. et al. (2001) Journal of virology 75, 12161-8. PMID: 11711607 2. Ferrara, C. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 12669-74. PMID: 21768335 3. Mizushima, T. et al. (2011) Genes to cells : devoted to molecular & cellular mechanisms 16, 1071-80. PMID: 22023369 4. DiLillo, DJ. et al. (2014) Nature medicine 20, 143-51. PMID: 24412922 5. Lee, J. et al. (2015) Immunity 42, 431-42. PMID: 25786175 6. Jing, Y. et al. (2015) PloS one 10, e0121788. PMID: 25816339 7. Blázquez-Moreno, A. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E5645-E5654. PMID: 28652325 8. de Haas, M. et al. (1996) Journal of immunology (Baltimore, Md. : 1950) 156, 2948-55. PMID: 8609432 9. Koene, HR. et al. (1997) Blood 90, 1109-14. PMID: 9242542
Nota	For research use only. Not suitable for clinical or therapeutic use.