InVivoMAb Anti-Human IL-11 Antibody (X203) (HB978010)

Name: InVivoMAb Anti-Human IL-11 Antibody (X203)
Brand: abinScience
SKU: HB978010
Price: 370 USD
Availability: InStock

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100ug
1mg

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SDS

Aperçu

Numéro de catalogue	HB978010
Description	InVivoMAb Anti-Human IL11 Antibody (X203) [X203] (HB978010) is a mouse monoclonal antibody detecting Interleukin-11 in FuncS. Suitable for Human.
Reactivité des espèces	Human
Applications	FuncS
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG2a, kappa
ID de clone	X203
Applications testées	WB
Cible	Interleukin-11, IL-11, Adipogenesis inhibitory factor, AGIF, Oprelvekin, IL11
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>95% as determined by SDS-PAGE.
Produits associés	pH 7.4 Dilution Buffer
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P20809
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. 1. Paul, SR. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 7512-6. PMID: 2145578 2. Harmegnies, D. et al. (2003) The Biochemical journal 375, 23-32. PMID: 12919066 3. Lamertz, L. et al. (2018) Science signaling 11. PMID: 30279168
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

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SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Human IL11 Antibody (X203)
Bioactivity

Detects recombinant human IL11-SUMO (Catalog No: HB978022) in indirect ELISA
Western blot

Western blot analysis was performed using anti-IL11 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human IL11 (Catalog No: HB978022)
Lane 2: negative control