InVivoMAb Anti-Human IL-11 Antibody (X203) (HB978010)

Name: InVivoMAb Anti-Human IL-11 Antibody (X203)
Brand: abinScience
SKU: HB978010
Price: 370 USD
Availability: InStock

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Спецификация:

100ug
1mg

Количество:

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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер	HB978010
Описание	InVivoMAb Anti-Human IL11 Antibody (X203) [X203] (HB978010) is a mouse monoclonal antibody detecting Interleukin-11 in FuncS. Suitable for Human.
Реактивность видов	Human
Применения	FuncS
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG2a, kappa
ID клона	X203
Проверенные приложения	WB
Цель	Interleukin-11, IL-11, Adipogenesis inhibitory factor, AGIF, Oprelvekin, IL11
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% as determined by SDS-PAGE.
Связанные продукты	pH 7.4 Dilution Buffer
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P20809
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. 1. Paul, SR. et al. (1990) Proceedings of the National Academy of Sciences of the United States of America 87, 7512-6. PMID: 2145578 2. Harmegnies, D. et al. (2003) The Biochemical journal 375, 23-32. PMID: 12919066 3. Lamertz, L. et al. (2018) Science signaling 11. PMID: 30279168
Примечание	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

Изображения

SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Human IL11 Antibody (X203)
Bioactivity

Detects recombinant human IL11-SUMO (Catalog No: HB978022) in indirect ELISA
Western blot

Western blot analysis was performed using anti-IL11 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human IL11 (Catalog No: HB978022)
Lane 2: negative control