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| カタログ番号 | MW444010 |
|---|---|
| 説明 |
InVivoMAb Anti-Mouse CD198/CCR8 Antibody (Iv0255) [Iv0255] (MW444010) is a mouse monoclonal antibody detecting C-C chemokine receptor type 8 in ELISA, Neutralization. Suitable for Mouse.
|
| 種反応性 | Mouse |
| アプリケーション | ELISA, Neutralization |
| 宿主種 | Mouse |
| クローン性 | Monoclonal |
| アイソタイプ | IgG2a, kappa |
| クローンID | Iv0255 |
| ターゲット | C-C chemokine receptor type 8, C-C CKR-8, CC-CKR-8, CCR-8, CDw198, Ccr8, Cmkbr8, Ter1 |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >95% as determined by SDS-PAGE. |
| 関連製品 | pH 7.4 Dilution Buffer |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P56484 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 背景 | C-C chemokine receptor type 8 (CD198/CCR8) is a ~40 kDa protein. G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18. Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways. Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage by supporting lymphoid cells IFN-gamma production. 1. Goya, I. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 1975-81. PMID: 9469461 2. Chensue, SW. et al. (2001) The Journal of experimental medicine 193, 573-84. PMID: 11238588 3. Kang, L. et al. (2020) Frontiers in immunology 11, 609400. PMID: 33613532 |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
| Isotype Control | Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173) (MF533507) |
SDS-PAGE for InVivoMAb Anti-Mouse CD198/CCR8 Antibody (Iv0255)
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