InVivoMAb Anti-Mouse CCR8 Antibody (Iv0265) (MW444020)

Name: InVivoMAb Anti-Mouse CCR8 Antibody (Iv0265)
Brand: abinScience
SKU: MW444020
Price: 370 USD
Availability: InStock

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Спецификация:

100ug
1mg

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Каталожный номер	MW444020
Описание	InVivoMAb Anti-Mouse CD198/CCR8 Antibody (Iv0265) [Iv0265] (MW444020) is a mouse monoclonal antibody detecting C-C chemokine receptor type 8 in ELISA, FCM, Neutralization. Suitable for Mouse. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Реактивность видов	Mouse
Применения	ELISA, FCM, Neutralization
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG2a, lambda
ID клона	Iv0265
Цель	C-C chemokine receptor type 8, C-C CKR-8, CC-CKR-8, CCR-8, CDw198, Ccr8, Cmkbr8, Ter1
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>95% by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P56484
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	C-C chemokine receptor type 8 (CD198/CCR8) is a ~40 kDa protein. G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18. Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways. Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage by supporting lymphoid cells IFN-gamma production. 1. Goya, I. et al. (1998) Journal of immunology (Baltimore, Md. : 1950) 160, 1975-81. PMID: 9469461 2. Chensue, SW. et al. (2001) The Journal of experimental medicine 193, 573-84. PMID: 11238588 3. Kang, L. et al. (2020) Frontiers in immunology 11, 609400. PMID: 33613532
Примечание	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173) (MF533507)