InVivoMAb Anti-Mouse IL-11 Antibody (Iv0284) (MB978010)

Name: InVivoMAb Anti-Mouse IL-11 Antibody (Iv0284)
Brand: abinScience
SKU: MB978010
Price: 191 USD
Availability: InStock

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Número de catálogo	MB978010
Descripción	InVivoMAb Anti-Mouse IL11 Antibody (Iv0284) [Iv0284] (MB978010) is a mouse monoclonal antibody detecting Interleukin-11 in ELISA, FCM, Neutralization, WB, in vivo research. Suitable for Mouse. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Reactividad de especies	Mouse
Aplicaciones	ELISA, FCM, Neutralization, WB, in vivo research
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG2a, kappa
ID de clon	Iv0284
Objetivo	Interleukin-11, IL-11, Il11
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P47873
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo	Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. 1. Morris, JC. et al. (1996) Experimental hematology 24, 1369-76. PMID: 8913282 2. Nishina, T. et al. (2012) Science signaling 5, ra5. PMID: 22253262 3. Barton, VA. et al. (1999) The Journal of biological chemistry 274, 5755-61. PMID: 10026196 4. Putoczki, TL. et al. (2013) Cancer cell 24, 257-71. PMID: 23948300
Nota	For research use only.
Isotype Control	Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

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SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Mouse IL11 Antibody (Iv0284)

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Datasheet

InVivoMAb Anti-Mouse IL-11 Antibody (Iv0284).pdf

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