InVivoMAb Anti-Mouse IL-11 Antibody (Iv0284) (MB978010)

Name: InVivoMAb Anti-Mouse IL-11 Antibody (Iv0284)
Brand: abinScience
SKU: MB978010
Price: 191 USD
Availability: InStock

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100ug
1mg

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Каталожный номер	MB978010
Описание	InVivoMAb Anti-Mouse IL11 Antibody (Iv0284) [Iv0284] (MB978010) is a mouse monoclonal antibody detecting Interleukin-11 in ELISA, FCM, Neutralization, WB, in vivo research. Suitable for Mouse. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Реактивность видов	Mouse
Применения	ELISA, FCM, Neutralization, WB, in vivo research
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG2a, kappa
ID клона	Iv0284
Цель	Interleukin-11, IL-11, Il11
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P47873
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Interleukin-11 (IL11) is a ~21 kDa protein. Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'. 1. Morris, JC. et al. (1996) Experimental hematology 24, 1369-76. PMID: 8913282 2. Nishina, T. et al. (2012) Science signaling 5, ra5. PMID: 22253262 3. Barton, VA. et al. (1999) The Journal of biological chemistry 274, 5755-61. PMID: 10026196 4. Putoczki, TL. et al. (2013) Cancer cell 24, 257-71. PMID: 23948300
Примечание	For research use only.
Isotype Control	Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

Изображения

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SDS-PAGE for InVivoMAb Anti-Mouse IL11 Antibody (Iv0284)

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InVivoMAb Anti-Mouse IL-11 Antibody (Iv0284).pdf

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