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| カタログ番号 | MX011010 | ||||
|---|---|---|---|---|---|
| 説明 |
InvivoMab Anti-Mouse IL2 Antibody (JES6-1A12) [JES6-1A12] (MX011010) is a rat monoclonal antibody detecting Aldesleukin in ELISA, FCM. Suitable for Mouse.
Highlights
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| 種反応性 | Mouse | ||||
| アプリケーション | ELISA, FCM | ||||
| 宿主種 | Rat | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG2b, kappa | ||||
| クローンID | JES6-1A12 | ||||
| ターゲット | Aldesleukin, IL-2, IL2, Interleukin-2, T-cell growth factor, TCGF | ||||
| エンドトキシンレベル | < 1 EU/mg | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P60568 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 背景 | Interleukin-2 (IL2) is a ~17 kDa protein. Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. 1. Mingari, MC. et al. (1984) Nature 312, 641-3. PMID: 6438535 2. Wang, X. et al. (2005) Science (New York, N.Y.) 310, 1159-63. PMID: 16293754 3. Stauber, DJ. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 2788-93. PMID: 16477002 4. Miyazaki, T. et al. (1994) Science (New York, N.Y.) 266, 1045-7. PMID: 7973659 5. Kirken, RA. et al. (1995) Cytokine 7, 689-700. PMID: 8580378 6. Osinalde, N. et al. (2015) Proteomics 15, 520-31. PMID: 25142963 7. Holbrook, NJ. et al. (1984) Proceedings of the National Academy of Sciences of the United States of America 81, 1634-8. PMID: 6608729 | ||||
| 注意事項 | For research use only. | ||||
| Isotype Control | Rat IgG2b Recombinant Isotype Control Antibody (LTF-2) (RF974107) |
SDS-PAGE for InvivoMab Anti-Mouse IL2 Antibody (JES6-1A12)
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