InVivoMAb Anti-Mouse SIRP alpha/CD172a Antibody (Ab25) (MX892030)

Name: InVivoMAb Anti-Mouse SIRP alpha/CD172a Antibody (Ab25)
Brand: abinScience
SKU: MX892030
Price: 370 USD
Availability: InStock

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100ug
1mg

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Aperçu

Numéro de catalogue	MX892030
Description	InVivoMAb Anti-Mouse SIRPA Antibody (Ab25) [Ab25] (MX892030) is a mouse monoclonal antibody detecting Tyrosine-protein phosphatase non-receptor type substrate 1 in ELISA, Neutralization. Suitable for Mouse.
Reactivité des espèces	Mouse
Applications	ELISA, Neutralization
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG2a, kappa
ID de clone	Ab25
Cible	BIT, Bit, Brain Ig-like molecule with tyrosine-based activation motifs, CD172 antigen-like family member A, CD172a, Inhibitory receptor SHPS-1, MFR, MYD1, Macrophage fusion receptor, MyD-1 antigen, PTPNS1, SHP substrate 1, SHPS-1, SHPS1, SIRP, SIRPA, Signal-regulatory protein alpha-1, Signal-regulatory protein alpha-2, Signal-regulatory protein alpha-3, Sirp-alpha-1, Sirp-alpha-2, Sirp-alpha-3, Tyrosine-protein phosphatase non-receptor type substrate 1, p84
Niveau d'endotoxines	< 1 EU/mg
Pureté	>95% as determined by SDS-PAGE.
Produits associés	pH 7.4 Dilution Buffer
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P97797
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	Tyrosine-protein phosphatase non-receptor type substrate 1 (CD172a/SIRPA) is a ~56 kDa protein. Immunoglobulin-like cell surface receptor for CD47. Acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. 1. Nakaishi, A. et al. (2008) Journal of molecular biology 375, 650-60. PMID: 18045614 2. Sarute, N. et al. (2019) PLoS biology 17, e3000137. PMID: 30726215
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Mouse IgG2a, kappa Recombinant Isotype Control Antibody (MOPC-173) (MF533507)

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SDS-PAGE

SDS-PAGE for InVivoMAb Anti-Mouse SIRPA Antibody (Ab25)
Bioactivity

Detects recombinant mouse CD172a/SIRPA (Catalog No: MX892011) in indirect ELISA

Reférences

Fiche technique

InVivoMAb Anti-Mouse SIRP alpha/CD172a Antibody (Ab25).pdf

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