InVivoMAb Anti-Mouse TIGIT Antibody (10A7) (MS739040)

Name: InVivoMAb Anti-Mouse TIGIT Antibody (10A7)
Brand: abinScience
SKU: MS739040
Price: 370 USD
Availability: InStock

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100ug
1mg

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Vista general

Número de catálogo	MS739040
Descripción	InVivoMAb Anti-Mouse TIGIT Antibody (10A7) [10A7] (MS739040) is a mouse monoclonal antibody detecting T-cell immunoreceptor with Ig and ITIM domains in ELISA, FCM, FuncS. Suitable for Mouse. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Reactividad de especies	Mouse
Aplicaciones	ELISA, FCM, FuncS
Especie huésped	Mouse
Clonalidad	Monoclonal
Isotipo	IgG2a, kappa
ID de clon	10A7
Aplicaciones probadas	WB
Objetivo	T-cell immunoreceptor with Ig and ITIM domains, TIGIT, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3, VSIG9, VSTM3
Nivel de endotoxinas	< 1 EU/mg
Pureza	>95% as determined by SDS-PAGE.
Productos asociados	pH 7.4 Dilution Buffer
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P86176
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Fondo	T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a ~26 kDa protein. Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades.
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

Imágenes

Western blot

Western blot analysis was performed using anti-TIGIT monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant mouse TIGIT (Catalog No: MS739012)
Lane 2: negative control