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InVivoMAb Anti-Mouse TIGIT Antibody (4D4) (MS739030)

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InVivoMAb Anti-Mouse TIGIT Antibody (4D4)

InVivoMAb Anti-Mouse TIGIT Antibody (4D4)

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100ug
1mg

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Overview

Catalog No.	MS739030
Description	InVivoMAb Anti-Mouse TIGIT Antibody (4D4) [4D4] (MS739030) is a mouse monoclonal antibody detecting T-cell immunoreceptor with Ig and ITIM domains in FuncS. Suitable for Mouse.
Species reactivity	Mouse
Applications	FuncS
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	4D4
Clonality	Monoclonal
Target	T-cell immunoreceptor with Ig and ITIM domains, V-set and transmembrane domain-containing protein 3, Tigit, Vstm3
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P86176
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a ~26 kDa protein. Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades.
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for InVivoMAb Anti-Mouse TIGIT Antibody (4D4)

References

Datasheet

InVivoMAb Anti-Mouse TIGIT Antibody (4D4).pdf

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InVivoMAb Anti-Mouse TIGIT Antibody (4D4)