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InVivoMAb Anti-Mouse TIGIT Antibody (10A7) (MS739040)

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InVivoMAb Anti-Mouse TIGIT Antibody (10A7)

InVivoMAb Anti-Mouse TIGIT Antibody (10A7)

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Spec:

100ug
1mg

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Overview
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References
Datasheet
SDS

Overview

Catalog No.	MS739040
Description	InVivoMAb Anti-Mouse TIGIT Antibody (10A7) [10A7] (MS739040) is a mouse monoclonal antibody detecting T-cell immunoreceptor with Ig and ITIM domains in ELISA, FCM, FuncS. Suitable for Mouse. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
Species reactivity	Mouse
Applications	ELISA, FCM, FuncS
Host species	Mouse
Isotype	IgG2a, kappa
Clone ID	10A7
Clonality	Monoclonal
Target	T-cell immunoreceptor with Ig and ITIM domains, V-set and transmembrane domain-containing protein 3, Tigit, Vstm3
Endotoxin level	Please contact with the lab for this information.
Purity	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Accession	P86176
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Background	T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a ~26 kDa protein. Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades.
Note	For research use only. Not suitable for clinical or therapeutic use.

Images

Western blot

Western blot analysis was performed using anti-TIGIT monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant mouse TIGIT (Catalog No: MS739012)
Lane 2: negative control

References

Datasheet

InVivoMAb Anti-Mouse TIGIT Antibody (10A7).pdf

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InVivoMAb Anti-Mouse TIGIT Antibody (10A7)