InVivoMAb Anti-Mouse TIGIT Antibody (10A7) (MS739040)

Name: InVivoMAb Anti-Mouse TIGIT Antibody (10A7)
Brand: abinScience
SKU: MS739040
Price: 370 USD
Availability: InStock

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100ug
1mg

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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	MS739040
説明	InVivoMAb Anti-Mouse TIGIT Antibody (10A7) [10A7] (MS739040) is a mouse monoclonal antibody detecting T-cell immunoreceptor with Ig and ITIM domains in ELISA, FCM, FuncS. Suitable for Mouse. Highlights ●Multi-Application — Validated across multiple applications. ●Flow Cytometry — Validated for flow cytometry applications.
種反応性	Mouse
アプリケーション	ELISA, FCM, FuncS
宿主種	Mouse
クローン性	Monoclonal
アイソタイプ	IgG2a, kappa
クローンID	10A7
テスト済みアプリケーション	WB
ターゲット	T-cell immunoreceptor with Ig and ITIM domains, TIGIT, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3, VSIG9, VSTM3
エンドトキシンレベル	< 1 EU/mg
純度	>95% as determined by SDS-PAGE.
関連製品	pH 7.4 Dilution Buffer
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P86176
形態	Liquid
保存バッファー	0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
背景	T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a ~26 kDa protein. Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades.
注意事項	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Mouse IgG2a (Fc Silence) Recombinant Isotype Control (MOPC 173) (MF533023)

イメージ

Western blot

Western blot analysis was performed using anti-TIGIT monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant mouse TIGIT (Catalog No: MS739012)
Lane 2: negative control