InVivoMAb Anti-Mouse TIGIT Antibody (4D4) (MS739030)

Name: InVivoMAb Anti-Mouse TIGIT Antibody (4D4)
Brand: abinScience
SKU: MS739030
Price: 370 USD
Availability: InStock

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100ug
1mg

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Numéro de catalogue	MS739030
Description	InVivoMAb Anti-Mouse TIGIT Antibody (4D4) [4D4] (MS739030) is a mouse monoclonal antibody detecting T-cell immunoreceptor with Ig and ITIM domains in FuncS. Suitable for Mouse.
Reactivité des espèces	Mouse
Applications	FuncS
Espèce hôte	Mouse
Clonalité	Monoclonal
Isotype	IgG2a, kappa
ID de clone	4D4
Cible	T-cell immunoreceptor with Ig and ITIM domains, TIGIT, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3, VSIG9, VSTM3
Niveau d'endotoxines	< 1 EU/mg
Pureté	>95% as determined by SDS-PAGE.
Produits associés	pH 7.4 Dilution Buffer
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P86176
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Contexte	T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a ~26 kDa protein. Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades.
Note	For research use only. Not suitable for clinical or therapeutic use.