InVivoMAb Anti-Mouse TIGIT Antibody (4D4) (MS739030)

Name: InVivoMAb Anti-Mouse TIGIT Antibody (4D4)
Brand: abinScience
SKU: MS739030
Price: 370 USD
Availability: InStock

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Спецификация:

100ug
1mg

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Каталожный номер	MS739030
Описание	InVivoMAb Anti-Mouse TIGIT Antibody (4D4) [4D4] (MS739030) is a mouse monoclonal antibody detecting T-cell immunoreceptor with Ig and ITIM domains in FuncS. Suitable for Mouse.
Реактивность видов	Mouse
Применения	FuncS
Хозяинский вид	Mouse
Клоональность	Monoclonal
Изотип	IgG2a, kappa
ID клона	4D4
Цель	T-cell immunoreceptor with Ig and ITIM domains, TIGIT, V-set and immunoglobulin domain-containing protein 9, V-set and transmembrane domain-containing protein 3, VSIG9, VSTM3
Уровень эндотоксинов	< 1 EU/mg
Чистота	>95% as determined by SDS-PAGE.
Связанные продукты	pH 7.4 Dilution Buffer
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P86176
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is a ~26 kDa protein. Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades.
Примечание	For research use only. Not suitable for clinical or therapeutic use.