Human ALPK1 Recombinant Protein (N-His) (HD668012)

Name: Human ALPK1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HD668012
Price: 211 USD
Availability: InStock

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1mg

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概要

カタログ番号	HD668012
説明	Recombinant Human ALPK1 Protein, N-His (HD668012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
発現システム	E. coli
アクセッション番号	Q96QP1
タンパク質長	Ser960-Thr1244
アプリケーション	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
種	Homo sapiens (Human)
性質	Recombinant
エンドトキシンレベル	Please contact with the lab for this information.
純度	>90% as determined by SDS-PAGE.
形態	Lyophilized
保存バッファー	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
再構成	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
発送	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	ALPK1, Alpha-protein kinase 1, Chromosome 4 kinase, EC:2.7.11.1, KIAA1527, LAK, Lymphocyte alpha-protein kinase
背景	Alpha-protein kinase 1 is a ~138 kDa protein. Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity. Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering pro-inflammatory NF-kappa-B signaling. May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A. May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A. 1. Milivojevic, M. et al. (2017) PLoS pathogens 13, e1006224. PMID: 28222186 2. Zimmermann, S. et al. (2017) Cell reports 20, 2384-2395. PMID: 28877472 3. Zhou, P. et al. (2018) Nature 561, 122-126. PMID: 30111836 4. Kozycki, CT. et al. (2022) Annals of the rheumatic diseases 81, 1453-1464. PMID: 35868845 5. Snelling, T. et al. (2023) Proceedings of the National Academy of Sciences of the United States of America 120, e2313148120. PMID: 38060563 6. Lee, CP. et al. (2016) Scientific reports 6, 25740. PMID: 27169898 7. Heine, M. et al. (2005) The Journal of biological chemistry 280, 25637-43. PMID: 15883161 8. Williams, LB. et al. (2019) Genetics in medicine : official journal of the American College of Medical Genetics 21, 2103-2115. PMID: 30967659
注意事項	For research use only

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参考文献

データシート

Human ALPK1 Recombinant Protein (N-His).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Human ALPK1 Recombinant Protein (N-His) (HD668012)

概要

イメージ

参考文献

データシート

SDS

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