Human ATP2C1 Recombinant Protein (N-His) (HX191032)

Name: Human ATP2C1 Recombinant Protein (N-His)
Brand: abinScience
SKU: HX191032
Price: 211 USD
Availability: InStock

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50ug
100ug
1mg

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Каталожный номер	HX191032
Описание	Recombinant Human ATP2C1 Protein, N-His (HX191032) expressed in E. coli, spanning Lys357-Pro548. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии	E. coli
Номер доступа	P98194
Длина белка	Lys357-Pro548
Применения	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды	Homo sapiens (Human)
Характер	Recombinant
Уровень эндотоксинов	Please contact with the lab for this information.
Чистота	>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса	23.46 kDa
Форма	Lyophilized
Буфер хранения	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	ATP-dependent Ca(2+) pump PMR1, ATP2C1, ATPase 2C1, Ca(2+)/Mn(2+)-ATPase 2C1, Calcium-transporting ATPase type 2C member 1, EC:7.2.2.10, KIAA1347, PMR1L, SPCA1, Secretory pathway Ca(2+)-transporting ATPase type 1
Фон	Calcium-transporting ATPase type 2C member 1 is a ~100 kDa protein. ATP-driven pump that supplies the Golgi apparatus with Ca(2+) and Mn(2+) ions, both essential cofactors for processing and trafficking of newly synthesized proteins in the secretory pathway. Within a catalytic cycle, acquires Ca(2+) or Mn(2+) ions on the cytoplasmic side of the membrane and delivers them to the lumenal side. The transfer of ions across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state. Plays a primary role in the maintenance of Ca(2+) homeostasis in the trans-Golgi compartment with a functional impact on Golgi and post-Golgi protein sorting as well as a structural impact on cisternae morphology. Responsible for loading the Golgi stores with Ca(2+) ions in keratinocytes, contributing to keratinocyte differentiation and epidermis integrity. 1. Fairclough, RJ. et al. (2003) The Journal of biological chemistry 278, 24721-30. PMID: 12707275 2. Dode, L. et al. (2005) The Journal of biological chemistry 280, 39124-34. PMID: 16192278 3. Lissandron, V. et al. (2010) Proceedings of the National Academy of Sciences of the United States of America 107, 9198-203. PMID: 20439740 4. Mukhopadhyay, S. et al. (2011) Proceedings of the National Academy of Sciences of the United States of America 108, 858-63. PMID: 21187401 5. Chen, J. et al. (2019) The Journal of biological chemistry 294, 7878-7891. PMID: 30923126 6. Dode, L. et al. (2006) The Journal of biological chemistry 281, 3182-9. PMID: 16332677 7. Behne, MJ. et al. (2003) The Journal of investigative dermatology 121, 688-94. PMID: 14632183
Примечание	For research use only

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Human ATP2C1 Recombinant Protein (N-His).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Formula

C₁ × V₁ = C₂ × V₂

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C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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