ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды
Homo sapiens (Human)
Характер
Recombinant
Уровень эндотоксинов
Please contact with the lab for this information.
Чистота
>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса
38.67 kDa
Форма
Lyophilized
Буфер хранения
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия
BIRC7, Baculoviral IAP repeat-containing protein 7, Baculoviral IAP repeat-containing protein 7 30kDa subunit, EC:2.3.2.27, KIAP, Kidney inhibitor of apoptosis protein, LIVIN, Livin, ML-IAP, MLIAP, Melanoma inhibitor of apoptosis protein, RING finger protein 50, RING-type E3 ubiquitin transferase BIRC7, RNF50, Truncated livin, p30-Livin, tLivin
Фон
Baculoviral IAP repeat-containing protein 7 is a ~32 kDa protein. Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine.
1. Kasof, GM. et al. (2001) The Journal of biological chemistry 276, 3238-46. PMID: 11024045
2. Vucic, D. et al. (2000) Current biology : CB 10, 1359-66. PMID: 11084335
3. Lin, JH. et al. (2000) Biochemical and biophysical research communications 279, 820-31. PMID: 11162435
4. Ma, L. et al. (2006) Cell death and differentiation 13, 2079-88. PMID: 16729033
5. Nachmias, B. et al. (2007) Apoptosis : an international journal on programmed cell death 12, 1129-42. PMID: 17294084
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