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| カタログ番号 | HA021012 |
|---|---|
| 説明 |
Recombinant Human BPIFA1/LunX Protein, N-His (HA021012) expressed in E. coli, spanning Gln20-Val256. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q9NP55 |
| タンパク質長 | Gln20-Val256 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 26.96 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | BPI fold-containing family A member 1, BPIFA1, LUNX, Lung-specific protein X, NASG, Nasopharyngeal carcinoma-related protein, PLUNC, Palate lung and nasal epithelium clone protein, SPLUNC1, SPURT, Secretory protein in upper respiratory tracts, Short PLUNC1, Tracheal epithelium-enriched protein, Von Ebner protein Hl |
| 背景 | BPI fold-containing family A member 1 is a ~26 kDa protein. Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. 1. Ning, F. et al. (2014) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 28, 5349-60. PMID: 25223608 2. Sayeed, S. et al. (2013) Infection and immunity 81, 285-91. PMID: 23132494 3. Liu, Y. et al. (2013) The American journal of pathology 182, 1519-31. PMID: 23499554 4. Walton, WG. et al. (2016) Biochemistry 55, 2979-91. PMID: 27145151 5. Garland, AL. et al. (2013) Proceedings of the National Academy of Sciences of the United States of America 110, 15973-8. PMID: 24043776 6. Hobbs, CA. et al. (2013) American journal of physiology. Lung cellular and molecular physiology 305, L990-L1001. PMID: 24124190 7. Lindahl, M. et al. (2001) Electrophoresis 22, 1795-800. PMID: 11425234 |
| 注意事項 | For research use only |
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