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| カタログ番号 | HA376012 |
|---|---|
| 説明 |
Recombinant Human C9orf72 Protein, N-His (HA376012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q96LT7 |
| タンパク質長 | Met1-Asn222 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | C9orf72, DENND9, DENNL72, Guanine nucleotide exchange factor C9orf72 |
| 背景 | Guanine nucleotide exchange factor C9orf72 is a ~54 kDa protein. Acts as a guanine-nucleotide releasing factor (GEF) for Rab GTPases by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP. Acts as a GEF for RAB39A which enables HOPS-mediated autophagosome-lysosome membrane tethering and fusion in mammalian autophagy. Component of the C9orf72-SMCR8 complex where both subunits display GEF activity and that regulates autophagy. As part of the C9orf72-SMCR8-WDR41 (CSW) complex, functions as GEF for RAB8A and RAB39B, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, also functions as GTPase activating protein (GAP) for RAB8A and RAB11A in vitro. 1. Sellier, C. et al. (2016) The EMBO journal 35, 1276-97. PMID: 27103069 2. Sullivan, PM. et al. (2016) Acta neuropathologica communications 4, 51. PMID: 27193190 3. Yang, M. et al. (2016) Science advances 2, e1601167. PMID: 27617292 4. Jung, J. et al. (2017) eLife 6. PMID: 28195531 5. Zhang, S. et al. (2023) Nature communications 14, 6360. PMID: 37821429 |
| 注意事項 | For research use only |
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