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Anti-Human C9orf72 Polyclonal Antibody (HA376014)

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Overview
Catalog No.HA376014
Description
Anti-Human C9orf72 Polyclonal Antibody (HA376014) is a rabbit polyclonal antibody detecting C9orf72. Suitable for Mouse, Rat, and Human.
Highlights
  • ●Multi-Species — Cross-reactive for translational research.
Species reactivityHuman, Mouse, Rat
ApplicationsELISA, IHC, WB
Host speciesRabbit
IsotypeIgG
Clonality Polyclonal
Immunogen E. coli - derived recombinant Human C9orf72 (Met1-Asn222).
Target C9orf72, DENND9, DENNL72, Guanine nucleotide exchange factor C9orf72
Endotoxin level Please contact with the lab for this information.
Purification Purified by antigen affinity column.
Accession Q96LT7
Form Liquid
Storage buffer 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Product Usage Information
Application Dilution
ELISA 1:5000-1:20000
IHC 1:50-1:500
WB 1:500-1:2000
Background

Guanine nucleotide exchange factor C9orf72 is a ~54 kDa protein. Acts as a guanine-nucleotide releasing factor (GEF) for Rab GTPases by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP. Acts as a GEF for RAB39A which enables HOPS-mediated autophagosome-lysosome membrane tethering and fusion in mammalian autophagy. Component of the C9orf72-SMCR8 complex where both subunits display GEF activity and that regulates autophagy. As part of the C9orf72-SMCR8-WDR41 (CSW) complex, functions as GEF for RAB8A and RAB39B, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, also functions as GTPase activating protein (GAP) for RAB8A and RAB11A in vitro.

1. Sellier, C. et al. (2016) The EMBO journal 35, 1276-97. PMID: 27103069
2. Sullivan, PM. et al. (2016) Acta neuropathologica communications 4, 51. PMID: 27193190
3. Yang, M. et al. (2016) Science advances 2, e1601167. PMID: 27617292
4. Jung, J. et al. (2017) eLife 6. PMID: 28195531
5. Zhang, S. et al. (2023) Nature communications 14, 6360. PMID: 37821429
Note For research use only
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Datasheet
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Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
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Formula
C₁ × V₁ = C₂ × V₂
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C₁ (Stock Conc.)
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V₁ (Stock Vol.)
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Working Solution
C₂ (Working Conc.)
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Anti-Human C9orf72 Polyclonal Antibody

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