Human C9orf72 Recombinant Protein (N-His) (HA376012)

Name: Human C9orf72 Recombinant Protein (N-His)
Brand: abinScience
SKU: HA376012
Price: 211 USD
Availability: InStock

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Overview

Catalog No.	HA376012
Description	Recombinant Human C9orf72 Protein, N-His (HA376012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE.. Highlights ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% as determined by SDS-PAGE.
Expression system	E. coli
Accession	Q96LT7
Protein length	Met1-Asn222
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Species	Homo sapiens (Human)
Nature	Recombinant
Endotoxin level	Please contact with the lab for this information.
Purity	>90% as determined by SDS-PAGE.
Form	Lyophilized
Storage buffer	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternate Names	C9orf72, DENND9, DENNL72, Guanine nucleotide exchange factor C9orf72
Background	Guanine nucleotide exchange factor C9orf72 is a ~54 kDa protein. Acts as a guanine-nucleotide releasing factor (GEF) for Rab GTPases by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP. Acts as a GEF for RAB39A which enables HOPS-mediated autophagosome-lysosome membrane tethering and fusion in mammalian autophagy. Component of the C9orf72-SMCR8 complex where both subunits display GEF activity and that regulates autophagy. As part of the C9orf72-SMCR8-WDR41 (CSW) complex, functions as GEF for RAB8A and RAB39B, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, also functions as GTPase activating protein (GAP) for RAB8A and RAB11A in vitro. 1. Sellier, C. et al. (2016) The EMBO journal 35, 1276-97. PMID: 27103069 2. Sullivan, PM. et al. (2016) Acta neuropathologica communications 4, 51. PMID: 27193190 3. Yang, M. et al. (2016) Science advances 2, e1601167. PMID: 27617292 4. Jung, J. et al. (2017) eLife 6. PMID: 28195531 5. Zhang, S. et al. (2023) Nature communications 14, 6360. PMID: 37821429
Note	For research use only

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Datasheet

Human C9orf72 Recombinant Protein (N-His).pdf

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Human C9orf72 Recombinant Protein (N-His) (HA376012)

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