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| カタログ番号 | HC541022 |
|---|---|
| 説明 |
Recombinant Human CAPRIN1 Protein, N-His (HC541022) expressed in E. coli, spanning Arg132-His252. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q14444 |
| タンパク質長 | Arg132-His252 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 16.66 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | CAPRIN1, Caprin-1, Cell cycle-associated protein 1, Cytoplasmic activation- and proliferation-associated protein 1, GPI-anchored membrane protein 1, GPI-anchored protein p137, GPI-p137, GPIAP1, GPIP137, M11S1, Membrane component chromosome 11 surface marker 1, RNA granule protein 105, RNG105, p137GPI |
| 背景 | Caprin-1 is a ~78 kDa protein. mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Plays an essential role in cytoplasmic stress granule formation. Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors. Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs. In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation. 1. Solomon, S. et al. (2007) Molecular and cellular biology 27, 2324-42. PMID: 17210633 2. Kim, TH. et al. (2019) Science (New York, N.Y.) 365, 825-829. PMID: 31439799 3. Pavinato, L. et al. (2023) Brain : a journal of neurology 146, 534-548. PMID: 35979925 4. Jia, X. et al. (2022) Science advances 8, eabo7112. PMID: 35977029 5. Sanders, DW. et al. (2020) Cell 181, 306-324.e28. PMID: 32302570 6. Yang, P. et al. (2020) Cell 181, 325-345.e28. PMID: 32302571 7. Guillén-Boixet, J. et al. (2020) Cell 181, 346-361.e17. PMID: 32302572 8. Kim, TH. et al. (2021) Proceedings of the National Academy of Sciences of the United States of America 118. PMID: 34074792 9. Toyama, Y. et al. (2022) Proceedings of the National Academy of Sciences of the United States of America 119, e2210492119. PMID: 36040869 |
| 注意事項 | For research use only |
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