Human CTLA-4 Recombinant Protein (C-His) (HB651011)

Name: Human CTLA-4 Recombinant Protein (C-His)
Brand: abinScience
SKU: HB651011
Price: 298 USD
Availability: InStock

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50ug
100ug
1mg

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SDS

Vista general

Número de catálogo	HB651011
Descripción	Recombinant Human CD152/CTLA4 Protein, C-His (HB651011) expressed in Mammalian Cells, spanning Met1-Asp161. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	Mammalian cells
Número de acceso	P16410
Longitud de proteína	Met1-Asp161
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Objetivo	HA, Hemagglutinin, Hemagglutinin HA1 chain, Hemagglutinin HA2 chain
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	18.55 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. RECONSTITUTION PROTOCOL 1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature. 2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial. 3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service. 4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down. 5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using. 6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	CD152, CTLA-4, CTLA4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4
Fondo	Cytotoxic T-lymphocyte protein 4 (CD152/CTLA4) is a ~24 kDa protein. Inhibitory receptor acting as a major negative regulator of T-cell responses. Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. CD152 is the therapeutic target of ipilimumab (Yervoy). 1. Schwartz, JC. et al. (2001) Nature 410, 604-8. PMID: 11279501 2. Stamper, CC. et al. (2001) Nature 410, 608-11. PMID: 11279502 3. Teft, WA. et al. (2006) Annual review of immunology 24, 65-97. PMID: 16551244 4. Linsley, PS. et al. (1991) The Journal of experimental medicine 174, 561-9. PMID: 1714933 5. Zheng, Y. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 1683-91. PMID: 18641304 6. Ramagopal, UA. et al. (2017) Proceedings of the National Academy of Sciences of the United States of America 114, E4223-E4232. PMID: 28484017
Nota	For research use only.

Imágenes

SDS-PAGE

SDS-PAGE for Recombinant Human CD152/CTLA4 Protein, C-His
Bioactivity

Detects Human CD152/CTLA4 Antibody in indirect ELISAs.
Bioactivity

Detects Ipilimumab in indirect ELISAs.
Bioactivity

Detects Nurulimab in indirect ELISAs.
Bioactivity

Detects Cadonilimab in indirect ELISAs.
Bioactivity

Detects Botensilimab in indirect ELISAs.
Bioactivity

Detected by Research Grade Gotistobart (Cat No.: HB651266) in indirect ELISA.
Western blot

Detected by Anti-CD152/CTLA4 monoclonal antibody (Catalog No: HS870396)
Bioactivity

Detected by Research Grade Quavonlimab (Catalog No: HB651066) in indirect ELISA
Bioactivity

Detected by Anti-Human CD152/CTLA4 Antibody (HL32) (Catalog No: HB651407) in indirect ELISA
Bioactivity

Detected by SAA1104 (Catalog No: HB651013) in indirect ELISA.
Bioactivity

Detected by Pavunalimab (Catalog No: HB613086) in indirect ELISA.
Bioactivity

Detected by Lorigerlimab (Catalog No: HB651086) in indirect ELISA.
Bioactivity

Detected by Tuvonralimab (Catalog No: HB651096) in indirect ELISA.
Bioactivity

Detected by Porustobart (Catalog No: HB651246) in indirect ELISA.
Bioactivity

Detected by Firastotug (Catalog No: HB651256) in indirect ELISA.
Bioactivity

Detected by Muzastotug (Catalog No: HB651276) in indirect ELISA.
Bioactivity

Detected by Sovipostobart (Catalog No: HB651286) in indirect ELISA.
Bioactivity

Detected by Evalstotug (Catalog No: HB651296) in indirect ELISA.
Bioactivity

Detected by Vilastobart (Catalog No: HB651306) in indirect ELISA.
Bioactivity

Detected by Tazlestobart (Catalog No: HB651316) in indirect ELISA.
Bioactivity

Immobilized HW630021 Human CD80/B7-1 Recombinant Protein (C-Fc) at 2 μg/mL(100 μL/well) can bind HB651011 Human CD152/CTLA4 Recombinant Protein (C-His), the EC 50 is 250 ng/mL.
Bioactivity

Immobilized MW630041 Mouse CD80 Recombinant Protein (C-Fc) at 2 μg/mL(100 μL/well) can bind HB651011 Human CD152/CTLA4 Recombinant Protein (C-His), the EC 50 is 354 ng/mL.