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| カタログ番号 | HV220012 |
|---|---|
| 説明 |
Recombinant Human CD158d/KIR2DL4 Protein, N-His (HV220012) expressed in E. coli, spanning Lys30-Gly219. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q99706 |
| タンパク質長 | Lys30-Gly219 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 23.23 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | CD158 antigen-like family member D, CD158D, CD158d, G9P, KIR-103AS, KIR103AS, KIR2DL4, Killer cell immunoglobulin-like receptor 2DL4, Killer cell inhibitory receptor 103AS, MHC class I NK cell receptor KIR103AS |
| 背景 | Killer cell immunoglobulin-like receptor 2DL4 is a ~41 kDa protein. Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy. May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells. Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response. 1. Rajagopalan, S. et al. (2006) PLoS biology 4, e9. PMID: 16366734 2. Rajagopalan, S. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 20596-601. PMID: 23184984 3. Fu, B. et al. (2017) Immunity 47, 1100-1113.e6. PMID: 29262349 4. Rajagopalan, S. et al. (1999) The Journal of experimental medicine 189, 1093-100. PMID: 10190900 5. Rajagopalan, S. et al. (2010) Science signaling 3, ra14. PMID: 20179272 |
| 注意事項 | For research use only |
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