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| カタログ番号 | HT018011 |
|---|---|
| 説明 |
Recombinant Human CD203c/ENPP3 Protein, C-Strep (HT018011) expressed in Mammalian Cells, spanning Leu48-Ile875. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | Mammalian cells |
| アクセッション番号 | O14638 |
| タンパク質長 | Leu48-Ile875 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 98.18 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Alkaline phosphodiesterase I, CD203c, Dinucleoside polyphosphatase, E-NPP 3, EC:3.1.4.1, EC:3.6.1.-, EC:3.6.1.9, ENPP3, Ectonucleotide pyrophosphatase/phosphodiesterase family member 3, NPP3, NPPase, Nucleotide diphosphatase, Nucleotide pyrophosphatase, PD-Ibeta, PDNP3, Phosphodiesterase I beta, Phosphodiesterase I/nucleotide pyrophosphatase 3 |
| 背景 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 is a ~100 kDa protein. Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Also hydrolyzes extracellular 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production, and is therefore involved in the regulation of innate immune response. 2',3'-cGAMP appears to be further processed to GMP, AMP and inorganic phosphate. Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. 1. Gorelik, A. et al. (2018) The FEBS journal 285, 2481-2494. PMID: 29717535 2. Jin-Hua, P. et al. (1997) Genomics 45, 412-5. PMID: 9344668 3. Mardjuki, R. et al. (2024) Cell reports 43, 114209. PMID: 38749434 4. Vollmayer, P. et al. (2003) European journal of biochemistry 270, 2971-8. PMID: 12846830 5. Bühring, HJ. et al. (2001) Blood 97, 3303-5. PMID: 11342463 |
| 注意事項 | For research use only |
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