Recombinant Human CD203c/ENPP3 Protein, C-Strep (HT018011) expressed in Mammalian Cells, spanning Leu48-Ile875. Purity: >90% by SDS-PAGE.
Highlights
●Mammalian Expression — Proper folding and native glycosylation.
●High Purity — >90% purity verified by SDS-PAGE.
Система экспрессии
Mammalian cells
Номер доступа
O14638
Длина белка
Leu48-Ile875
Применения
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды
Homo sapiens (Human)
Характер
Recombinant
Уровень эндотоксинов
Please contact with the lab for this information.
Чистота
>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса
98.18 kDa
Форма
Lyophilized
Буфер хранения
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия
Alkaline phosphodiesterase I, CD203c, Dinucleoside polyphosphatase, E-NPP 3, EC:3.1.4.1, EC:3.6.1.-, EC:3.6.1.9, ENPP3, Ectonucleotide pyrophosphatase/phosphodiesterase family member 3, NPP3, NPPase, Nucleotide diphosphatase, Nucleotide pyrophosphatase, PD-Ibeta, PDNP3, Phosphodiesterase I beta, Phosphodiesterase I/nucleotide pyrophosphatase 3
Фон
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 is a ~100 kDa protein. Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Also hydrolyzes extracellular 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production, and is therefore involved in the regulation of innate immune response. 2',3'-cGAMP appears to be further processed to GMP, AMP and inorganic phosphate. Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells.
1. Gorelik, A. et al. (2018) The FEBS journal 285, 2481-2494. PMID: 29717535
2. Jin-Hua, P. et al. (1997) Genomics 45, 412-5. PMID: 9344668
3. Mardjuki, R. et al. (2024) Cell reports 43, 114209. PMID: 38749434
4. Vollmayer, P. et al. (2003) European journal of biochemistry 270, 2971-8. PMID: 12846830
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