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Human PD-L1 Recombinant Protein (C-His) (HV974011)

データシート 製品共有 情報コピー
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
Human PD-L1 Recombinant Protein (C-His)
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概要
カタログ番号HV974011
説明
Recombinant Human CD274/PD-L1/B7-H1 Protein, C-His (HV974011) expressed in Mammalian Cells, spanning Met1-Arg238. Purity: >90% by SDS-PAGE.
Highlights
  • ●His-Tagged — N-terminal 6×His tag for IMAC purification.
  • ●Mammalian Expression — Proper folding and native glycosylation.
  • ●High Purity — >90% purity verified by SDS-PAGE.
発現システムMammalian cells
アクセッション番号Q9NZQ7
タンパク質長Met1-Arg238
アプリケーションELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
種Homo sapiens (Human)
性質 Recombinant
テスト済みアプリケーション WB
ターゲット B7 homolog 1, B7-H1, B7H1, CD274, PD-L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, Programmed cell death 1 ligand 1, Programmed death ligand 1
エンドトキシンレベル Please contact with the lab for this information.
純度 >90% as determined by SDS-PAGE.
予測分子量 28.40 kDa
形態 Lyophilized
保存バッファー Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
再構成 Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet.

RECONSTITUTION PROTOCOL
1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature.
2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial.
3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service.
4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down.
5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using.
6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
発送 In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
安定性と保存 Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名B7 homolog 1, B7-H1, B7H1, CD274, PD-L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, Programmed cell death 1 ligand 1, Programmed death ligand 1
背景

Programmed cell death 1 ligand 1 (CD274/PD-L1) is a ~33 kDa protein. Plays a critical role in induction and maintenance of immune tolerance to self. As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response. Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10). Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis. CD274 is the therapeutic target of atezolizumab (Tecentriq) and durvalumab (Imfinzi).

1. Freeman, GJ. et al. (2000) The Journal of experimental medicine 192, 1027-34. PMID: 11015443
2. Mezzadra, R. et al. (2017) Nature 549, 106-110. PMID: 28813410
3. Burr, ML. et al. (2017) Nature 549, 101-105. PMID: 28813417
4. Huang, X. et al. (2019) Cancer immunology research 7, 1580-1590. PMID: 31399419
5. Kennedy, A. et al. (2023) The EMBO journal 42, e111556. PMID: 36727298
6. Dong, H. et al. (1999) Nature medicine 5, 1365-9. PMID: 10581077
7. Hou, J. et al. (2020) Nature cell biology 22, 1264-1275. PMID: 32929201
注意事項 For research use only.
イメージ
  • Human PD-L1 Recombinant Protein (C-His)

    SDS-PAGE

    SDS-PAGE for Recombinant Human CD274/PD-L1/B7-H1 Protein, C-His

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detects Avelumab in indirect ELISAs.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detects Envafolimab in indirect ELISAs.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detects Atezolizumab in indirect ELISAs.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detects Adebrelimab in indirect ELISAs.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detects Human CD274/PD-L1/B7-H1 Antibody in indirect ELISAs.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detects Manelimab in indirect ELISAs.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detects Cosibelimab in indirect ELISAs.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detects Acasunlimab in indirect ELISAs.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detects Erfonrilimab in indirect ELISAs.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detects Human PD-L1 Antibody in indirect ELISAs.

  • Human PD-L1 Recombinant Protein (C-His)

    Western blot

    Detected by Anti-CD274/PD-L1/B7-H1 monoclonal antibody (Catalog No: HV974216)

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Palverafusp alfa (Catalog No: HB265026) in indirect ELISA.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Nebratamig (Catalog No: HC336146) in indirect ELISA.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Enristomig (Catalog No: HC336156) in indirect ELISA.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Ragistomig (Catalog No: HC336166) in indirect ELISA.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Xirestomig (Catalog No: HC336176) in indirect ELISA.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Simridarlimab (Catalog No: HC359056) in indirect ELISA.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Umizortamig (Catalog No: HF004466) in indirect ELISA.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Pm8002 (Catalog No: HB941236) in indirect ELISA.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Socazolimab (Catalog No: HV974176) in indirect ELISA.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Tagitanlimab (Catalog No: HV974186) in indirect ELISA.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Betifisolimab (Catalog No: HV974196) in indirect ELISA.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Lesabelimab (Catalog No: HV974206) in indirect ELISA.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Danburstotug (Catalog No: HV974236) in indirect ELISA.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Retlirafusp Alfa (Catalog No: HV974406) in indirect ELISA.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Benmelstobart (Catalog No: HV974416) in indirect ELISA.

  • Human PD-L1 Recombinant Protein (C-His)

    Bioactivity

    Detected by Sotiburafusp alfa (Catalog No: HV974436) in indirect ELISA.

参考文献
データシート
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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Human PD-L1 Recombinant Protein (C-His)

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