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| カタログ番号 | HV379012 |
|---|---|
| 説明 |
Recombinant Human CD316/IGSF8 Protein, N-His (HV379012) expressed in E. coli, spanning Arg28-Thr300. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q969P0 |
| タンパク質長 | Arg28-Thr300 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 31.61 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | CD316, CD81 partner 3, CD81P3, EWI-2, EWI2, Glu-Trp-Ile EWI motif-containing protein 2, IGSF8, IgSF8, Immunoglobulin superfamily member 8, KCT-4, KCT4, Keratinocytes-associated transmembrane protein 4, LIR-D1, PGRL, Prostaglandin regulatory-like protein |
| 背景 | Immunoglobulin superfamily member 8 is a ~65 kDa protein. Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity. Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities. In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation. Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry. 1. Stipp, CS. et al. (2001) The Journal of biological chemistry 276, 40545-54. PMID: 11504738 2. Stipp, CS. et al. (2003) The Journal of cell biology 163, 1167-77. PMID: 14662754 3. Kettner, S. et al. (2007) Molecular and cellular biology 27, 7718-26. PMID: 17785435 4. Gordón-Alonso, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 689-700. PMID: 22689882 5. Potel, J. et al. (2013) Cellular microbiology 15, 1234-52. PMID: 23351194 6. Whitaker, EE. et al. (2019) Viruses 11. PMID: 31757023 7. Li, Y. et al. (2024) Cell 187, 2703-2716.e23. PMID: 38657602 |
| 注意事項 | For research use only |
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