Anti-Human CD316/IGSF8 Recombinant Antibody (SAA1612) (HV379013)

Name: Anti-Human CD316/IGSF8 Recombinant Antibody (SAA1612)
Brand: abinScience
SKU: HV379013
Price: 196 USD
Availability: InStock

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50ug
100ug
1mg

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Overview
Images
References
Datasheet
SDS

Overview

Catalog No.

HV379013

Species reactivity

Human

Applications

ELISA

Host species

Mouse

Isotype

IgG2a, kappa

Clone ID

SAA1612

Clonality

Monoclonal

Target

EWI2, IGSF8, CD316, Glu-Trp-Ile EWI motif-containing protein 2, Keratinocytes-associated transmembrane protein 4, LIR-D1, Prostaglandin regulatory-like protein, CD81P3, EWI-2, KCT-4, CD81 partner 3, Immunoglobulin superfamily member 8, IgSF8, KCT4, PGRL

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q969P0

RRID

Anti-Human CD316/IGSF8 Antibody (SAA1612) (abinScience Cat# HV379013, RRID:AB_3727373)

Form

Liquid

Storage buffer

0.01M PBS pH 7.4

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:2000-1:20000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Background

Immunoglobulin superfamily member 8 (CD316/IGSF8) is a ~65 kDa protein. Member of the immunoglobulin superfamily (IgSF) that links tetraspanin-enriched microdomains to the actin cytoskeleton and plays several important roles in innate and adaptive immunity. Acts as an inducible receptor of HSPA8 on dendritic cells to enhance the CCL21/SLC-dependent migration of activated mature dendritic cells while attenuating their antigen-specific stimulatory capacities. In complex with alpha-actinins ACTN1 and ACTN4, regulates actin dynamics in the immune synapse and subsequent T-cell activation. Inhibits the entry of several viruses such as hepatitis C Virus (HCV) or HIV-1. Mechanistically, promotes a change in CD81 organization at the plasma membrane by significantly restricting its diffusion which in turn influences CD81 interaction with Claudin-1/CLDN1, preventing CLDN1 from acting as a co-receptor required for HCV entry.

1. Stipp, CS. et al. (2001) The Journal of biological chemistry 276, 40545-54. PMID: 11504738

2. Stipp, CS. et al. (2003) The Journal of cell biology 163, 1167-77. PMID: 14662754

3. Kettner, S. et al. (2007) Molecular and cellular biology 27, 7718-26. PMID: 17785435

4. Gordón-Alonso, M. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 689-700. PMID: 22689882

5. Potel, J. et al. (2013) Cellular microbiology 15, 1234-52. PMID: 23351194

6. Whitaker, EE. et al. (2019) Viruses 11. PMID: 31757023

7. Li, Y. et al. (2024) Cell 187, 2703-2716.e23. PMID: 38657602

Note

For research use only.

Images

SDS-PAGE

SDS-PAGE for Anti-Human CD316/IGSF8 Antibody (SAA1612)

References

Datasheet

Anti-Human CD316/IGSF8 Recombinant Antibody (SAA1612).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human CD316/IGSF8 Recombinant Antibody (SAA1612) (HV379013)

Overview

Images

References

Datasheet

SDS

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