Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución
Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet.
RECONSTITUTION PROTOCOL
1. Allow the product to be reconstituted and the reconstitution diluent to reach room temperature.
2. Tap or briefly centrifuge the product vial before opening to dislodge any lyophilized material that may be dispersed on the wall or cap of the vial.
3. Use the diluent and stock concentration recommended in the product datasheet. If preparing a stock concentration higher than recommended, contact Technical Service.
4. After adding the diluent, re-cap the vial and invert gently by hand or place on a slow rocking platform to allow the reconstitution diluent to coat all the surfaces inside the vial. Note: Do not mix by vortexing or by pipetting the material up and down.
5. Allow the vial to sit at room temperature with gentle agitation for at least 15 minutes before aliquotting or using.
6. Store the reconstituted material in single use aliquots in polypropylene or siliconized tubes. Aliquots of 10 μL or larger are recommended.
Envío
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Receptor tyrosine-protein kinase erbB-2 (CD340/ERBB2) is a ~137 kDa protein. Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. CD340 is the therapeutic target of trastuzumab (Herceptin) and trastuzumab deruxtecan (Enhertu).
Nota
For research use only.
Imágenes
SDS-PAGE
SDS-PAGE for Recombinant Human CD340/ERBB2 Protein, C-His
Bioactivity
Detects Ertumaxomab in indirect ELISAs.
Bioactivity
Detects M802 in indirect ELISAs.
Bioactivity
Detects Margetuximab in indirect ELISAs.
Bioactivity
Detects Zanidatamab in indirect ELISAs.
Bioactivity
Detects Zenocutuzumab in indirect ELISAs.
Bioactivity
Detects Runimotamab in indirect ELISAs.
Western blot
Detected by Anti-CD340/ERBB2 monoclonal antibody (Catalog No: HW664107)
Bioactivity
Detected by Cinrebafusp alfa (Catalog No: HC336186) in indirect ELISA.
Bioactivity
Detected by MEDI4276 (Catalog No: HY286566) in indirect ELISA.
Bioactivity
Detected by Anbenitamab (Catalog No: HY286106) in indirect ELISA.
Bioactivity
Detected by Anvatabart (Catalog No: HY286156) in indirect ELISA.
Bioactivity
Detected by Calotatug (Catalog No: HY286746) in indirect ELISA.
Bioactivity
Detected by Iv0231 (Catalog No: HY286030) in indirect ELISA.
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