Human CLEC4D/CLECSF8 Recombinant Protein (N-Fc) (HV778021)

Name: Human CLEC4D/CLECSF8 Recombinant Protein (N-Fc)
Brand: abinScience
SKU: HV778021
Price: 298 USD
Availability: InStock

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Número de catálogo	HV778021
Descripción	Recombinant Human CD368/CLEC4D Protein, N-Fc (HV778021) expressed in Mammalian Cells, spanning Cys39-Asn215. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	Mammalian cells
Número de acceso	Q8WXI8
Longitud de proteína	Cys39-Asn215
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	48.49 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	C-type lectin domain family 4 member D, C-type lectin superfamily member 8, C-type lectin-like receptor 6, CD368, CLEC-6, CLEC4D, CLECSF8, DC-associated C-type lectin 3, Dectin-3, Dendritic cell-associated C-type lectin 3, MCL
Fondo	C-type lectin domain family 4 member D is a ~24 kDa protein. Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells. Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. The heterodimer formed with CLEC6A is active against fungal infection. 1. Miyake, Y. et al. (2013) Immunity 38, 1050-62. PMID: 23602766 2. Zhu, LL. et al. (2013) Immunity 39, 324-34. PMID: 23911656 3. Arce, I. et al. (2004) European journal of immunology 34, 210-20. PMID: 14971047
Nota	For research use only

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Datasheet

Human CLEC4D/CLECSF8 Recombinant Protein (N-Fc).pdf

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