Anti-Human CD368/CLEC4D Recombinant Antibody (9B9), PerCP (HV778147)

Name: Anti-Human CD368/CLEC4D Recombinant Antibody (9B9), PerCP
Brand: abinScience
SKU: HV778147
Price: 268 USD
Availability: InStock

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Catalog No.	HV778147
Species reactivity	Human
Applications	FCM
Host species	Mouse
Isotype	IgG2b, kappa
Clone ID	9B9
Conjugation	PerCP
Clonality	Monoclonal
Target	CD368, CLECSF8, C-type lectin domain family 4 member D, C-type lectin superfamily member 8, MCL, C-type lectin-like receptor 6, CLEC4D, CLEC-6
Endotoxin level	Please contact with the lab for this information.
Associated products	Mouse IgG2b, kappa Recombinant Isotype Control Antibody (MPC-11), PerCP
Accession	Q8WXI8
Form	Liquid
Storage buffer	0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Stability and Storage	Store at 4°C for 12 months. Protect from light. Do not freeze.
Background	C-type lectin domain family 4 member D (CD368/CLEC4D) is a ~24 kDa protein. Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells. Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. The heterodimer formed with CLEC6A is active against fungal infection. 1. Miyake, Y. et al. (2013) Immunity 38, 1050-62. PMID: 23602766 2. Zhu, LL. et al. (2013) Immunity 39, 324-34. PMID: 23911656 3. Arce, I. et al. (2004) European journal of immunology 34, 210-20. PMID: 14971047
Note	For flow cytometric staining, the suggested use of this reagent is 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. For research use only.

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Anti-Human CD368/CLEC4D Recombinant Antibody (9B9), PerCP.pdf

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Anti-Human CD368/CLEC4D Recombinant Antibody (9B9), PerCP (HV778147)

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