Human IL-10 R alpha Recombinant Protein (C-Fc) (HC614021)

Name: Human IL-10 R alpha Recombinant Protein (C-Fc)
Brand: abinScience
SKU: HC614021
Price: 298 USD
Availability: InStock

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50ug
100ug
1mg

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Número de catálogo	HC614021
Descripción	Recombinant Human CDw210a/IL10RA Protein, C-Fc (HC614021) expressed in Mammalian Cells, spanning Met1-Asn235. Purity: >90% by SDS-PAGE. Highlights ●Fc Fusion — Enhanced stability with Protein A/G purification compatibility. ●Mammalian Expression — Proper folding and native glycosylation. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	Mammalian cells
Número de acceso	Q13651
Longitud de proteína	Met1-Asn235
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	52.94 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	CD210, CDw210a, IL-10 receptor subunit alpha, IL-10R subunit 1, IL-10R subunit alpha, IL-10R1, IL-10RA, IL10R, IL10RA, Interleukin-10 receptor subunit 1, Interleukin-10 receptor subunit alpha
Fondo	Interleukin-10 receptor subunit alpha is a ~63 kDa protein. Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. 1. Yoon, SI. et al. (2006) The Journal of biological chemistry 281, 35088-96. PMID: 16982608 2. Usacheva, A. et al. (2002) Journal of immunology (Baltimore, Md. : 1950) 169, 1302-8. PMID: 12133952 3. Shi, J. et al. (2016) Cell death & disease 7, e2133. PMID: 26962683
Nota	For research use only

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Bioactivity

Immobilized HB997011 Human IL10 Recombinant Protein (C-His) at 2 μg/mL(100 μL/well) can bind HC614021 Human CDw210a/IL10RA Recombinant Protein (C-Fc), the EC 50 is 325 ng/mL.

Referencias

Datasheet