

| Numéro de catalogue | HP125012 |
|---|---|
| Description |
Recombinant Human CECR2 Protein, N-His (HP125012) expressed in E. coli, spanning Met424-His538. Purity: >90% by SDS-PAGE.
Highlights
|
| Système d'expression | E. coli |
| Numéro d'accès | Q9BXF3 |
| Longueur de protéine | Met424-His538 |
| Applications | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Espèces | Homo sapiens (Human) |
| Nature | Recombinant |
| Niveau d'endotoxines | Please contact with the lab for this information. |
| Pureté | >90% as determined by SDS-PAGE. |
| Masse moléculaire prédite | 16.19 kDa |
| Forme | Lyophilized |
| Tampon de stockage | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot. |
| Reconstitution | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Expédition | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Stabilité et stockage | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Noms alternatifs | CECR2, Cat eye syndrome critical region protein 2, Chromatin remodeling regulator CECR2, KIAA1740 |
| Contexte | Chromatin remodeling regulator CECR2 is a ~164 kDa protein. Regulatory subunit of the ATP-dependent CERF-1 and CERF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. The complexes do not have the ability to slide mononucleosomes to the center of a DNA template. The CERF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the CERF-5 ISWI chromatin remodeling complex. Plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes. 1. Banting, GS. et al. (2005) Human molecular genetics 14, 513-24. PMID: 15640247 2. Filippakopoulos, P. et al. (2012) Cell 149, 214-31. PMID: 22464331 3. Flynn, EM. et al. (2015) Structure (London, England : 1993) 23, 1801-1814. PMID: 26365797 4. Oppikofer, M. et al. (2017) EMBO reports 18, 1697-1706. PMID: 28801535 5. Liu, L. et al. (2002) Genomics 79, 124-36. PMID: 11827465 |
| Note | For research use only |
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