Human CTNS Recombinant Protein (N-GST & C-His) (HF632022)

Name: Human CTNS Recombinant Protein (N-GST & C-His)
Brand: abinScience
SKU: HF632022
Price: 211 USD
Availability: InStock

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Numéro de catalogue	HF632022
Description	Recombinant Human CTNS Protein, N-GST & C-His (HF632022) expressed in E. coli, spanning Ser22-Ser120. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Système d'expression	E. coli
Numéro d'accès	O60931
Longueur de protéine	Ser22-Ser120
Applications	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Espèces	Homo sapiens (Human)
Nature	Recombinant
Niveau d'endotoxines	Please contact with the lab for this information.
Pureté	>90% as determined by SDS-PAGE.
Masse moléculaire prédite	38.92 kDa
Forme	Lyophilized
Tampon de stockage	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Reconstitution	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Expédition	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	CTNS, Cystinosin
Contexte	Cystinosin is a ~41 kDa protein. Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes. Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis. In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes. Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity. 1. Kalatzis, V. et al. (2001) The EMBO journal 20, 5940-9. PMID: 11689434 2. Kalatzis, V. et al. (2004) Human molecular genetics 13, 1361-71. PMID: 15128704 3. Taranta, A. et al. (2008) American journal of physiology. Renal physiology 294, F1101-8. PMID: 18337546 4. Ruivo, R. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, E210-7. PMID: 22232659 5. Deshpande, AA. et al. (2018) Scientific reports 8, 3442. PMID: 29467429 6. Adelmann, CH. et al. (2020) Nature 588, 699-704. PMID: 33208952 7. Guo, X. et al. (2022) Cell 185, 3739-3752.e18. PMID: 36113465 8. Chiaverini, C. et al. (2012) FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26, 3779-89. PMID: 22649030
Note	For research use only

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Human CTNS Recombinant Protein (N-GST & C-His).pdf

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