Human CUL4A Recombinant Protein (N-His) (HC663022)

Name: Human CUL4A Recombinant Protein (N-His)
Brand: abinScience
SKU: HC663022
Price: 211 USD
Availability: InStock

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Número de catálogo	HC663022
Descripción	Recombinant Human CUL4A Protein, N-His (HC663022) expressed in E. coli, spanning Gln570-Ala759. Purity: >90% by SDS-PAGE. Highlights ●His-Tagged — N-terminal 6×His tag for IMAC purification. ●E. coli Expression — High-yield, cost-effective production. ●High Purity — >90% purity verified by SDS-PAGE.
Sistema de expresión	E. coli
Número de acceso	Q13619
Longitud de proteína	Gln570-Ala759
Aplicaciones	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Especies	Homo sapiens (Human)
Naturaleza	Recombinant
Nivel de endotoxinas	Please contact with the lab for this information.
Pureza	>90% as determined by SDS-PAGE.
Peso molecular predicho	24.44 kDa
Forma	Lyophilized
Buffer de almacenamiento	Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Reconstitución	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Envío	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	CUL-4A, CUL4A, Cullin-4A
Fondo	Cullin-4A is a ~87 kDa protein. Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. 1. Higa, LA. et al. (2003) Nature cell biology 5, 1008-15. PMID: 14578910 2. Wertz, IE. et al. (2004) Science (New York, N.Y.) 303, 1371-4. PMID: 14739464 3. Hu, J. et al. (2004) Nature cell biology 6, 1003-9. PMID: 15448697 4. Nag, A. et al. (2004) Cancer research 64, 8152-5. PMID: 15548678 5. Matsuda, N. et al. (2005) DNA repair 4, 537-45. PMID: 15811626 6. Wang, H. et al. (2006) Molecular cell 22, 383-94. PMID: 16678110 7. Higa, LA. et al. (2006) Nature cell biology 8, 1277-83. PMID: 17041588 8. Han, J. et al. (2013) Cell 155, 817-29. PMID: 24209620 9. Chen, SH. et al. (2018) The EMBO journal 37. PMID: 30166453 10. Maiani, E. et al. (2021) Nature 592, 799-803. PMID: 33854232
Nota	For research use only

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Datasheet

Human CUL4A Recombinant Protein (N-His).pdf

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