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| カタログ番号 | HX187032 |
|---|---|
| 説明 |
Recombinant Human DEFA5 Protein, N-GST & C-His (HX187032) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q01523 |
| タンパク質長 | Glu20-Arg94 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | DEF5, DEFA5, Defensin alpha 5, Defensin-5, HD5(20-94), HD5(23-94), HD5(29-94), HD5(56-94), HD5(63-94) |
| 背景 | Defensin alpha 5 is a ~10 kDa protein. Host-defense peptide that maintains sterility in the urogenital system. Has antimicrobial activity against a wide range of bacteria, including Gram-negative E.coli, P.aeruginosa and S.typhimurium, and Gram-positive E.aerogenes, S.aureus, B.cereus, E.faecium and L.monocytogenes. Confers resistance to intestinal infection by S.typhimurium. Exhibits antimicrobial activity against enteric commensal bacteria such as B.adolescentis, L.acidophilus, B.breve, L.fermentum, B.longum and S.thermophilus. Binds to bacterial membranes and causes membrane disintegration. 1. Ghosh, D. et al. (2002) Nature immunology 3, 583-90. PMID: 12021776 2. Salzman, NH. et al. (2003) Nature 422, 522-6. PMID: 12660734 3. Ericksen, B. et al. (2005) Antimicrobial agents and chemotherapy 49, 269-75. PMID: 15616305 4. de Leeuw, E. et al. (2009) FEBS letters 583, 2507-12. PMID: 19589339 5. Spencer, JD. et al. (2012) PloS one 7, e31712. PMID: 22359618 6. Rajabi, M. et al. (2012) The Journal of biological chemistry 287, 21615-27. PMID: 22573326 7. Schroeder, BO. et al. (2015) Mucosal immunology 8, 661-71. PMID: 25354318 8. Wang, C. et al. (2015) Journal of medicinal chemistry 58, 3083-93. PMID: 25782105 9. Ehmann, D. et al. (2019) Proceedings of the National Academy of Sciences of the United States of America 116, 3746-3751. PMID: 30808760 |
| 注意事項 | For research use only |
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