Anti-Human DEFA5 Polyclonal Antibody (HX187014)

Name: Anti-Human DEFA5 Polyclonal Antibody
Brand: abinScience
SKU: HX187014
Price: 168 USD
Availability: InStock

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Overview

Catalog No.

HX187014

Species reactivity

Human

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human DEFA5 (Glu20-Arg94).

Target

HD5(20-94), DEF5, Defensin-5, DEFA5, Defensin, alpha 5

Purification

Purified by antigen affinity column.

Accession

Q01523

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Background

Defensin alpha 5 (DEFA5) is a ~10 kDa protein. Host-defense peptide that maintains sterility in the urogenital system. Has antimicrobial activity against a wide range of bacteria, including Gram-negative E.coli, P.aeruginosa and S.typhimurium, and Gram-positive E.aerogenes, S.aureus, B.cereus, E.faecium and L.monocytogenes. Confers resistance to intestinal infection by S.typhimurium. Exhibits antimicrobial activity against enteric commensal bacteria such as B.adolescentis, L.acidophilus, B.breve, L.fermentum, B.longum and S.thermophilus. Binds to bacterial membranes and causes membrane disintegration.

1. Ghosh, D. et al. (2002) Nature immunology 3, 583-90. PMID: 12021776

2. Salzman, NH. et al. (2003) Nature 422, 522-6. PMID: 12660734

3. Ericksen, B. et al. (2005) Antimicrobial agents and chemotherapy 49, 269-75. PMID: 15616305

4. de Leeuw, E. et al. (2009) FEBS letters 583, 2507-12. PMID: 19589339

5. Spencer, JD. et al. (2012) PloS one 7, e31712. PMID: 22359618

6. Rajabi, M. et al. (2012) The Journal of biological chemistry 287, 21615-27. PMID: 22573326

7. Schroeder, BO. et al. (2015) Mucosal immunology 8, 661-71. PMID: 25354318

8. Wang, C. et al. (2015) Journal of medicinal chemistry 58, 3083-93. PMID: 25782105

9. Ehmann, D. et al. (2019) Proceedings of the National Academy of Sciences of the United States of America 116, 3746-3751. PMID: 30808760

Note

For research use only.

Images

References

Datasheet

Anti-Human DEFA5 Polyclonal Antibody.pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

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Anti-Human DEFA5 Polyclonal Antibody (HX187014)

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Datasheet

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