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| カタログ番号 | HB888022 |
|---|---|
| 説明 |
Recombinant Human ERCC2 Protein, N-His (HB888022) expressed in E. coli, spanning Cys489-Leu760. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P18074 |
| タンパク質長 | Cys489-Leu760 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Homo sapiens (Human) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 33.38 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | BTF2 p80, Basic transcription factor 2 80 kDa subunit, CXPD, DNA 5'-3' helicase XPD, DNA excision repair protein ERCC-2, DNA repair protein complementing XP-D cells, EC:5.6.2.3, ERCC2, General transcription and DNA repair factor IIH helicase subunit XPD, TFIIH 80 kDa subunit, TFIIH basal transcription factor complex 80 kDa subunit, TFIIH p80, TFIIH subunit XPD, XPD, XPDC, Xeroderma pigmentosum group D-complementing protein |
| 背景 | General transcription and DNA repair factor IIH helicase subunit XPD is a ~86 kDa protein. ATP-dependent 5'-3' DNA helicase. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, not absolutely essential for minimal transcription in vitro. Required for transcription-coupled nucleotide excision repair (NER) of damaged DNA; recognizes damaged bases. Sequestered in chromatin on UV-damaged DNA. When complexed to CDK-activating kinase (CAK), involved in transcription by RNA polymerase II. 1. Kokic, G. et al. (2019) Nature communications 10, 2885. PMID: 31253769 2. Sung, P. et al. (1993) Nature 365, 852-5. PMID: 8413672 3. Coin, F. et al. (1998) Nature genetics 20, 184-8. PMID: 9771713 4. Tirode, F. et al. (1999) Molecular cell 3, 87-95. PMID: 10024882 5. Coin, F. et al. (2007) Molecular cell 26, 245-56. PMID: 17466626 6. Mathieu, N. et al. (2013) Current biology : CB 23, 204-12. PMID: 23352696 7. Aibara, S. et al. (2021) Nature 594, 124-128. PMID: 33902107 |
| 注意事項 | For research use only |
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