Anti-Human ERCC2 Polyclonal Antibody (HB888014)

Name: Anti-Human ERCC2 Polyclonal Antibody
Brand: abinScience
SKU: HB888014
Price: 168 USD
Availability: InStock

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Overview
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References
Datasheet
SDS

Overview

Catalog No.

HB888014

Description

Anti-Human ERCC2 Polyclonal Antibody (HB888014) is a rabbit polyclonal antibody detecting ERCC2. Suitable for Human and Mouse.

Highlights

●Multi-Species — Cross-reactive for translational research.

Species reactivity

Human, Mouse

Applications

ELISA, IHC, WB

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human ERCC2 (Cys489-Leu760).

Target

BTF2 p80, Basic transcription factor 2 80 kDa subunit, CXPD, DNA 5'-3' helicase XPD, DNA excision repair protein ERCC-2, DNA repair protein complementing XP-D cells, EC:5.6.2.3, ERCC2, General transcription and DNA repair factor IIH helicase subunit XPD, TFIIH 80 kDa subunit, TFIIH basal transcription factor complex 80 kDa subunit, TFIIH p80, TFIIH subunit XPD, XPD, XPDC, Xeroderma pigmentosum group D-complementing protein

Endotoxin level

Please contact with the lab for this information.

Purification

Purified by antigen affinity column.

Accession

P18074

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

Product Usage Information

Application	Dilution
ELISA	1:5000-1:20000
IHC	1:50-1:500
WB	1:500-1:2000

Background

General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2) is a ~86 kDa protein. ATP-dependent 5'-3' DNA helicase. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, not absolutely essential for minimal transcription in vitro. Required for transcription-coupled nucleotide excision repair (NER) of damaged DNA; recognizes damaged bases. Sequestered in chromatin on UV-damaged DNA. When complexed to CDK-activating kinase (CAK), involved in transcription by RNA polymerase II.

1. Kokic, G. et al. (2019) Nature communications 10, 2885. PMID: 31253769

2. Sung, P. et al. (1993) Nature 365, 852-5. PMID: 8413672

3. Coin, F. et al. (1998) Nature genetics 20, 184-8. PMID: 9771713

4. Tirode, F. et al. (1999) Molecular cell 3, 87-95. PMID: 10024882

5. Coin, F. et al. (2007) Molecular cell 26, 245-56. PMID: 17466626

6. Mathieu, N. et al. (2013) Current biology : CB 23, 204-12. PMID: 23352696

7. Aibara, S. et al. (2021) Nature 594, 124-128. PMID: 33902107

Note

For research use only

Images

References

Datasheet

Anti-Human ERCC2 Polyclonal Antibody.pdf

Download SDS PDF

Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.

Mass

Concentration

Volume

Molecular Weight *

g/mol

Formula

C₁ × V₁ = C₂ × V₂

Enter any 3 of the 4 values to solve for the unknown.

Stock Solution

C₁ (Stock Conc.)

V₁ (Stock Vol.)

Working Solution

C₂ (Working Conc.)

V₂ (Working Vol.)

Recombinant Proteins

Antibodies

Assay Kits

Anti-Human ERCC2 Polyclonal Antibody (HB888014)

Overview

Images

References

Datasheet

SDS

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